Erectile dysfunction is a problem that recently often complicates the lives of modern men. The prevalence of the disease makes medical scientists around the world to invent and develop the means for its cure.
Erectile Dysfunction
There are three main chemicals used in the manufacture of drugs to fight against the erectile dysfunction are: Sildenafil, Vardenafil and Tadalafil. We would like to pay special attention to the advantages of the latter, since it is the main active component of the drug Tazalis, which has shown itself to very good advantage in the treatment of ED in men.
It is clear that Sildenafil and Vardenafil are chemicals of quite the same good quality and safety, as they are used in the manufacture of products with world-wide reputation. And yet, we would like to highlight some of the superior Tadalafil parameters, which will make a choice of some very meticulous patients, or patients whose condition is aggravated by other diagnoses, in favor of Tazalis, as they might need to use the most easily perceived drug for ED treatment. It should be noted that the differences between Tadalafil, Sildenafil and Vardenafil are not fundamental, and the final choice remains for the patient and his physician.
Thus, all three active chemical substances have practically the same effect on the patient’s body, which is blocking type 5 phosphodiesterase (PDE-5). Accumulation of this enzyme in the male body prevents the release of nitric oxide, which stimulates muscle relaxation and the inflow of blood to the penis, if the erection is normal. Drugs, such as Tazalis, turn the accumulation of PDE-5 back, thereby making a normal erection possible.
In the description of any drug such an aspect as its selectivity is present, which is an aimed orientation at the particular problem. The selectivity of the three above-mentioned drugs is very high, although they all more or less act on other enzymes in the body. Usually it does not cause any clearly marked reactions in patients, but a manifestation of the possible side effects of the drug is dependent on how a substance affects the enzymes not involved in the process of erection. In particular, with respect to PDE-6, responsible for photoperception, Sildenafil’s selective effect on the PDE-5 is 10 times higher, for Vardenafil it’s 15 times, tadalafil – 780 times. Thus, the deterioration of color vision is almost not observed in patients taking Tazalis.
One also needs to pay attention to the performance indicator of the drug as a semi-excretion. It shows, for what period the half of the accepted norm of the drug is derived from the patient and gives an idea of the duration of action. For Sildenafil and Vardenafil this period is almost the same and averages out 4 hours. For Tadalafil it’s 17.5 hours. This suggests that the duration of the drug containing Tadalafil, such as Tazalis, is much longer than of other similar drugs. Moreover, Tadalafil has no tendency to accumulation in the body that at a regular use could lead to the increased potential side effects.
Tadalafil PDE5 Formula
Pharmacists are also paying attention to the fact that the action of some drugs may be reduced in the case of the simultaneous taking with food. For Sildenafil and Vardenafil the risk of the partial loss of the effect exists if the fat content in food is 57%. The food, consumed by the patient, has no effect on Tadalafil.
Based on the foregoing, we can safely say that the drugs for impotence, that contain tadalafil as the main active ingredient, are somewhat surpass those in which the main component differs. For safety, all approved chemicals are at high level and can cause no anxiety in patients. But concerning the time of action, Tadalafil is far ahead of its competitors. And this is important, as in the case of Tazalis patient finds himself in a less dependent of the drug taking situation, which allows him more freedom to plan his personal live. It is recommended to take Tazalis once a day, but by taking the appropriate dose once each 36 hours, the patient mostly can not to worry about the body failure at a certain time. A lower cost, coupled with all of the above facts, can help the patient to finally opt for the Tazalis.
